宋耀华教授  博士生导师

1961.03出生

电话：0512-65880877-3626                  

传真：0512-65880929

邮箱：yaohua_song1@yahoo.com/yhsong@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号苏州大学独墅湖校区一期703号楼3626室,邮编215123

个人简历：

宋耀华，苏州大学特聘教授，博士生导师。1984年获首都医科大学医学学士学位， 1991年获瑞典Uppsala大学医用化学博士学位。2006年-2011年担任美国癌症领域排名第一的MD安德森癌症中心分子病理系副教授， 并于2009年获MD Anderson Cancer Center杰出导师奖。2011年9月起被特聘为苏州大学唐仲英血液学研究中心教授。博士论文课题是关于胃酸分泌原理的研究，首次克隆了人胃壁细胞的氢-钾ATP酶的β亚基。参与了目前已在全世界广泛应用治疗胃及十二指肠溃疡特效药，氢-钾ATP酶抑制剂-Omeprazole（奥美拉唑）的研发。

目前共计发表百余篇SCI论文，其中包括著名的PNAS, Lancet, Cell子刊Cell Reports, Signal Transduction and Targeted Therapy, Journal of Clinical Oncology, Leukemia, Nature Review Cardiology等。实验室的论文受到国内外同行广泛关注和认可，BioArt及生物谷等平台对论文成果进行了专题报道。

主持国自然面上项目及国家血液系统疾病临床医学研究中心委托课题，并参与江苏省六大高峰创新团队。已培养多名博士/硕士，其中多名研究生获得国家奖学金和“优秀研究生”、“优秀毕业生”荣誉。在保证质量的前提下，本组研究生均顺利取得了毕业证和学位证。同时陆续指导多名本科生进行科学研究，部分已有文章发表在国际知名SCI刊物。

主要研究方向:

1.生物钟对骨骼肌功能的调节作用

2.卫星细胞修复骨骼肌电离辐射损伤的分子机制

3.胃癌的发生发展机制研究

4.骨髓增生异常综合征的发病机制研究

代表性论著:

1.Sha Geng, Song-Bai Liu, Wei He, Xiangbin Pan, Yi Sun, Ting Xue, Shiyuan Han, Jing Lou, Ying Chang , Jiqing Zheng, Xinghong Shi, YangxinLi*, Yao-Hua Song*. Deletion of TECRL promotes skeletal muscle repair by up-regulating EGR2.Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2317495121.

2.Jing Lou, Sha Geng,Wei He,Song-Bai Liu,Xinghong Shi, Ying Chang, Shiyuan Han, Panting Qian, Hesham M Amin, Yao-Hua Song*,YangxinLi*, Jin Zhou. Zyxin inhibits the epithelial-mesenchymal transition process in gastric cancer by upregulating SIRT1. MedComm (2020). 2023 Sep 3;4(5):e357.

3.Yingxue Hao,, Ting Xue, Song-Bai Liu, Sha Geng, Xinghong Shi, Panting Qian, Wei He, Jiqing Zheng, Yanfang Li, Jing Lou, Tianze Shi, Ge Wang, Xiaoxiao Wang, Yanli Wang, YangxinLi*, Yao-Hua Song*. Loss of CRY2 promotesregenerative myogenesis by enhancing PAX7 expression and satellite cell proliferation.MedComm. 2023 Jan 9;4(1):e202.

4.Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-HuaSong*, Yangxin Li*. Ribosome biogenesis in disease: new players and therapeutic targets. Signal Transduction and Targeted Therapy. 2023 Jan9;8(1):15.

5.Jiqing Zheng, Jing Lou, Yanfang Li, Panting Qian, Wei He, Yingxue Hao, Ting Xue, YangxinLi*, Yao-Hua  Song*. Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice. Cell Reports. 2022 Jun14;39(11):110939.

6.Hong Yao, Li Huo, Nana Ping, Hong Liu, HongzhiLi,  Zixuan  Ding,  Hongjie  Shen, Jundan Xie, Qiaocheng Qiu,  Liang  Ma,  Airui  Jiang,  Qian  Wang,  Depei  Wu, Xiaofei Yang, Yaohua Song*, Suning Chen*.Recurrent mutations in multiple components of the SWI/SNF complex in myelodysplastic syndromes and acute myeloid leukaemia.British Journal of Haematology. 2022Jan;196(2):441-444.

7.ChangjuQu^#,YaohuaSong^#,JiaYin^#,YunjuMa,LiqingKang,ZhengLi,Haiping Dai, Xiaming Zhu, Lei Yu, Depei Wu, Xiaowen Tang. Decitabine may improve CAR-T efficacy in refractory/relapsed acute leukemia patients carrying TP53 alterations. Bone Marrow Transplant. 2021 Jul;56(7):1710-1713.

8.Yangxin Li*, Hui Huang, Bin Liu, Yu Zhang, Xiangbin Pan, Xi-Yong Yu, Zhenya Shen*, Yao-Hua Song*. Inflammasomes as therapeutic targets in human diseases.Signal Transduction and Targeted Therapy.2021 Jul 2;6(1):247.

9.Chaofan Wu, Hui Ding, Shuochen Wang, Yangxin Li, Song-Bai Liu, Xiaoxiao Wang, Jiqing Zheng, Ting Xue, Hesham M Amin, Yao-Hua Song*, Jin Zhou*. DAXX inhibits cancer stemness and epithelial-mesenchymal transition in gastric cancer. British Journal of Cancer. 2020May;122(10):1477-1485.

10.Congcong Shen, Jin Zhou*, Xiaoxiao Wang, Xi-Yong Yu, Chun Liang, Bin Liu, Xiangbin Pan, Qiong Zhao, Jenny Lee Song, Jiajun Wang, Meiyu Bao, Chaofan Wu, Yangxin Li*, Yao-Hua Song*. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.EBioMedicine.2017 Feb;16:238-250.

11.Nana Ping^#, Aining Sun^#, Yao-Hua Song^#, Qinrong Wang^#, Jia Yin,Wenxiu Cheng, Yang Xu, Lijun Wen, Hong Yao, Liang Ma, Huiying Qiu, Changgeng Ruan, Depei Wu, and Suning Chen. Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia. Leukemia. 2017 Jan;31(1):195-202.

12.Yangxin Li, Jin Zhou, Yao-Hua Song, Xi-Yong Yu. Dominant and recessive imprinting of exosomes from parent cells. Nature Review Cardiology.2017 Aug;14(8):491.

13.Jin Zhou, Bin Liu, Chun Liang, Yangxin Li*, Yao-Hua Song*. Cytokine Signaling in Skeletal Muscle Wasting. Trends in Endocrinology & Metabolism.2016 May;27(5):335-347.

14.XiaowenTang^#,Yao-HuaSong^#,AiningSun,XiamingZhu,ChanggengRuan,Depei Wu. Successful treatment of relapsed acute myeloid leukemia without chemotherapy. Journal of Clinical Oncology.2016 May 1;34(13):e117-9.

15.Yao-Hua Song. Why tyrosinase for treatment of melanoma. Lancet.1997 Jul 12;350(9071):82-3.

课程教学及招生信息:

主持骨骼肌与人体健康（本科生新生研讨课），该课深受学生喜爱，在教学质量测评中连续获得优秀。