放射医学与防护英文刊

Radiation Medicine and Protection英文刊发表FLASH放疗综述被SCI刊引用24次

时间:2023-01-19来源:必赢国际437官方点击:1097

视频内容为Radiation Medicine and Protection2020年创刊号上发表的综述Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues

本综述聚焦放射医学领域的热点——超高剂量率(FLASH)放疗生物学机制的最新进展,提出了正常细胞和肿瘤细胞在受照后自由基产额、DNA损伤修复以及免疫调控等方面的差异导致FLASH效应的假设,并进行系统深入的论证,对于阐明FLASH效应的生物学机制、促进该技术在临床中的应用具有重要的参考价值。https://www.sciencedirect.com/science/article/pii/S2666555720300083,作者简介及文章摘要如下:


 Abstract

 Different from conventional radiotherapy (CONV-RT), FLASH radiotherapy (FLASH-RT) delivers a single high dose at a mean dose rate ≥40 Gy/s in milliseconds to achieve similar tumor control to CONV-RT while sparing normal tissues from detrimental injury. It provides an intriguing perspective in improving clinical outcomes for tumor patients as well as a novel way to enhance the differential responses between normal and tumor tissues. However, its mechanisms remain largely unclear. In this paper, we review the currently available publications on FLASH-RT and parse the probable mechanisms of three major aspects including the production of reactive oxygen species, DNA damage response, and immunoreaction. Experiments specifically designed to disclose the intrinsic difference between normal and malignant cells in response to FLASH-RT and CONV-RT are necessary to prove these hypotheses.



周光明  国际宇航科学院院士


苏州大学苏州医学院放射医学与防护学院、必赢国际437官方



该综述发表以来,已被SCI收录期刊引用24次,其中大多位于Q1Q2区,说明该文有较大的国际影响力。


Radiation Medicine and Protection (《放射医学与防护(英文),简称RMP)20203月创刊,由中国科协主管、中华医学会主办,中国疾病预防控制中心辐射防护与核安全医学所和苏州大学放射医学与防护学院暨必赢国际437官方联合创办。


 RMP致力于电离辐射效应、医疗照射防护研究,推行剂量最优化,降低国民的剂量负担,促进核能与核技术的合理应用。该刊是我国放射医学与辐射防护专业领域唯一一本英文期刊,入选卓越期刊计划高起点新刊。


  • DOAJScopusCSCD收录。

  • 20226月,获得第一个CiteScore引用分1.4,在Health Professions: Emergency Medical Services中排名学科第2,位于Q1区。